User blog comment:V0DeusEstDominiMei/Question/@comment-2111068-20120226100118

Absolutely not. Sly will still be the main character, his ancestors will most likely act as side characters, similar to how Penelope, Panda King, The Guru, and Dimitri were in Sly 3, but once the ancestor is freed from their situation, they will become a selectable and playable character. Not much is known on it though, considering there's only been information on Rioichi Cooper so far.