Mz. Ruby: Well, I'll unleash my mighty mojo magic upon you. If you repeat what I do, you'll dodge it just fine. If not, you'll get zapped.
Sly Cooper: A little voodoo Simon Says, huh? Sounds easy enough.
― Before the boss battle[src]
Sly confronted Mz. Ruby inside her skull temple. She proposed they both play a nice game of Simon Says, as a way to test Sly's reflexes. She explained the rules of the game, of which Sly was to dodge her voodoo magic or face a painful zap. Determined to take her down, Sly accepted the challenge, finding it not so difficult.
Sly faced off against the evil alligator in three rounds. Each involved the same process, in which Sly was to dodge the incoming projectiles of Mz. Ruby's voodoo magic as he attempted to make his way towards her. After being ultimately beaten in all three rounds, Mz Ruby admitted to Sly that he had some rhythm, but warned him that it would not serve him good if he was to go after the next Fiendish Five member, the Panda King, as he was tough, with a capital T. However, Sly felt he could manage it, should the Panda King be anything like her and the previously defeated members.
Mz. Ruby Vexed
After Mz. Ruby was defeated, Sly managed to swipe what she stole from the Thievius Raccoonus, the page detailing the Invisibility technique developed by Slytunkhamen Cooper, Sly's pioneering ancestor. Shortly after, Carmelita Fox arrived to pin the cuffs on Mz. Ruby, as her production of ghosts was ruled illegal in the World Peace Accord of '71, earning her a life sentence behind bars.
Afterward, the gang decided to relax and take some time off, enjoying the tropical sunshine and working on their tans in preparation for their next caper.