Hey Sly! I thought you said Mesa City was going to be loud and busy. This looks more like a ghost town!
― Bentley describing Mesa City[src]
Sly and the gang traveled to Mesa City to confront Muggshot, the dastardly chief enforcer of the Fiendish Five. Upon arriving, Sly exited the van and climbed to the top of the large gate blocking the entrance. He found that the whole city was deserted and wondered why. Bentley, feeling frightened by the situation, suggested they leave, but Sly was eager to try out the Ninja Spire Jump on the lights ahead of him.
Sly ventured through the outskirts of the city, facing Muggshot's guards. Along the way, he encountered an old train car with some flashing lasers serving as electronic floor sensors. Should Sly take one careless step, he would be a goner. After getting past the security forces in the area, Sly stole the first of Muggshot's treasure keys and then entered his base of operations.
There are 40 clue bottles to collect in this area, and the vault is located on a small piece of land, at the end of a rope that stretches above a car dangling halfway over the edge of the cliff, just after the first pounding pistons. The vault's combination is 3-1-4.
A little bit of higher mathematics, and voila! Dial in 3-1-4.