They were huge, wine red insects with four wings, and small, dark-purple spots in their backs. If they spotted an intruder wandering around their territory, they would attack and try to suck their blood. If they succeeded, they would show their satisfaction with an expression of fullness before spitting out the blood in disgust. They were quite agile due to their ability of flight. Sly's binocucom says that they all enjoy Sunday picnics.
One of the mosquitoes was used as transportation for Sly during the boss battle with Mz. Ruby and was later destroyed by her voodoo spell.
- "Vicious Voodoo"