So he's holed up in Mesa City, huh? I've always wanted to go to that thriving American boomtown.
― Sly Cooper[src]
As the gang made the trip to Mesa City, Sly Cooper studied up on the second Fiendish Five member Muggshot, learning that he grew up as the "runt of the litter," always being bullied and picked on. The only friends he looked up to were gangsters found on the big screen, and he knew right away that was what he wanted to be. Determined to earn the respect he wanted, Muggshot spent the rest of his youth working real hard to become a tough-as-nails brute. He got revenge on his former bullies and eventually took control of Mesa City, building a massive casino and forcing all of the citizens to flee town.
|"A Rocky Start"|
|Sly and the gang arrived in Mesa City and found it odd that it was all of a sudden deserted, but he soon discovered what happened. Sly battles some of Muggshot's goons in order to get into his turf.|
|Sly entered Muggshot's main base of operations and discovered that the bulldog resided inside the giant fire hydrant located on top of the largest casino.|
|Sly ventured into the Boneyard Casino, one of the few buildings still populated within Mesa City, which was apparently falling apart and filling with water.|
|"Murray's Big Gamble"|
|Murray had to make a run for one of the treasure keys, but he needed covering fire. Sly was to use the blasting station in order to protect Murray from Muggshot's goons.|
|"At the Dog Track"|
|Murray was challenged to a race by Muggshot's goons, with the big prize being a treasure key. To earn it, Murray had to beat the other racers in three laps.|
|"Two to Tango"|
|Sly explored some rooftops and encountered Carmelita Fox, who attempted to arrest him once more.|
|"Back Alley Heist"|
|Sly had to explore some back allies to find another treasure key, but he needed to be careful not to fall from the tall buildings.|
|"Straight to the Top"|
|The treasure key was placed inside a skylight made of thick glass. Sly was forced to do some serious climbing in order to destroy the glass and retrieve it.|
|Finally, Sly found himself face-to-face with Muggshot. The dastardly bulldog was not too keen on letting Sly take back what was his without a fight. Sly had to finish Muggshot off to reclaim what was his.|
Muggshot's section of the Thievius Raccoonus contained an entry for Sly's gun-slinging ancestor, "Tennessee Kid" Cooper, whose specialty was the Rail Walk and Rail Slide, which he perfected during his long time of thievery in the Old West.
With the INTERPOL authorities arriving, getting out of town was tougher for the gang than getting in. Having just missed Sly once again, Carmelita Fox went ahead and busted Muggshot. This marked the end of Muggshot's gambling empire, and the citizens of Mesa City's soon returned home. Sly and the gang continued to enjoy the rest of their time in America before returning to Paris, ready to tackle their next opponent.